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The FAGenomicH project: towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity

Luca Fontanesi, Raffaele Fronza, Emilio Scotti, Michela Colombo, Camilla Speroni, Lucia Tognazzi, Giuliano Galimberti, Daniela Giovanna Calò, Elena Bonora, Manuela Vargiolu, Giovanni Romeo, Rita Casadio, Vincenzo Russo
DOI: 10.4081/ijas.2009.s2.87 | Published: 2010-01-05 16:49:39 | Views: 346
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Abstract


Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs.

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the Italian Journal of Animal Science [eISSN 1828-051X] is the official journal of the Animal Science and Production Association and it is published by PAGEPress®, Pavia, Italy. Reg. Pavia, n. 2/2010-INF. All credits and honors to PKP for their OJS.